Healthy Ageing and Bioactive Lipids: Prevention of Fatty Liver and Alzheimer’s Disease

Teruyoshi YANAGITAa, b, c

aProfessor Emeritus of Saga University, JAPAN, and National ANCASH University, PERU, bVisiting Professor of Chinese Ocean University, CHINA, and Nishi Kyushu University, JAPAN,  Director of Saga Regional Industry Support Center: Saga Food & Cosmetic Laboratoryc

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Food factors are considered to be critical for health promotion and play an important role in the prevention of metabolic syndrome (life-style related diseases). Metabolic syndrome is typical common disease, such as abdominal obesity, dyslipidemia, hypertension and diabetes mellitus that contribute to increased cardiovascular morbidity and mortality. Metabolic syndrome is also closely associated with non-alcoholic fatty liver disease (NAFLD), and cognitive disorder and Alzheimer’s disease. The quality and quantity of dietary lipids have been recognized as contributing factors in the development and prevention of these diseases. Recent evidences suggest the preventive role of dietary bioactive lipids. In this context, we review the beneficial effects of conjugated linoleic acid (CLA), n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA, EPA, DPA, DHA, and THA) and phospholipids on metabolic syndrome and related diseases such as fatty liver and insulin resistance. Phospholipids have been reported to provide favorable effects against neurodegenerative disorders, including dementia, Alzheimer’s disease, Parkinson’s disease and age-related cognitive decline. The studies indicate that n-3 LCPUFA-phospholipids reduce the oxidative stress and inflammation in the brain hippopotamus and prevent the accumulation of amyloid β (A β) and then prevent the memory loss and the cognitive disorders. In conclusion, functional bioactive lipids may apply as supplements and/or functional food ingredients to relieve metabolic syndrome and neurodegenerative diseases.

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